p53 Polymorphism in Oral Lichen Planus

Oral lichen planus (OLP) is a chronic relapsing inflammatory disease. It involves T-lymphocyte aggression targeted to the basal layer of oral mucosa.p53 plays central role in prevention normal cells from development malignant phenotype. Somatic alterations p53 cause defects function. Wild type an important repairable damage cell due cellular stresses. Over-expression, as well polymorphic variants Mouse double minute 2(MDM2), have effects on disturbances. In addition, degradation by E6 protein high-risk human papillomavirus also suggested one mechanisms which attenuate responses carcinogenesis. Polymorphisms are anticipated measurable disturbance Polymorphism codon 72 exon 4 gene first and most commonly known polymorphism this gene. The presence has been demonstrated early marker dysplasia Potentially Malignant Disorders. This review discusses about indicator genetic predisposition neoplastic transformation OLP.